MAPK8 and Alzheimer disease: Co-occurrence of p-tau with p-JNK and p-CaMKII in DNs does not demonstrate a physical interaction in these structures, but does suggest that DNs could be sites of early tau phosphorylation, especially p-tau181, which is used as an early CSF and plasma biomarker that indicates amyloid pathology and predicts AD [19, 65, 107].