APP and Alzheimer disease: AAV-mediated A6-GFP overexpression recapitulated the localization of endogenous A6, which was also found in membranes of neurons and DN (marked by BACE1 or APP) in 5XFAD transgenic (Fig. 4B) and APP-NLGF knock-in (Fig. 4C) amyloid model mice, and brains from AD patients (Fig. 4D, E) where it could play a role in amyloid-induced membrane repair.