We searched Medline and ISI Web of Science for reports published before Mar 31, 2025, with the search terms [“spinocerebellar ataxia” AND “biomarker” OR “neurofilament light chain (NfL)” OR “MRI“ OR “digital outcome“ AND “prospective“ AND “electrophysiological” OR “follow-up“ OR “longitudinal“]. The gene discussed is NEFL; the disease is cerebellar ataxia.