SOAT1 and inflammatory bowel disease: The suggestion that the JAK-STAT pathway could be directly involved in fibrogenesis was raised by the association of specific JAK2 SNPs in IBD patients, with ileocolonic disease and increased risk of stricturing complications.39–41 Fibroblasts, and especially activated fibroblast, are the main cells responsible for excessive ECM deposition and therefore inducing fibrosis.