SOAT1 and inflammatory bowel disease: By regulating both innate and adaptive mucosal immunity, the JAK-STAT pathway is directly involved in the inflammatory process and clearance of pathogens, summarized in several excellent reviews.32,33 In the context of IBD, important proinflammatory cytokines like oncostatin-M, IFN-γ, IL-12, IL-22, IL-23, IL-6, IL-9 signal via the JAK-STAT signaling pathway.