SOAT1 and myelofibrosis: Myelofibrosis is a progressive myeloid disorder characterized by the deposition of reticulin, causing fibrosis and an increased risk of leukemic transformation.54 The pivotal role of the JAK-STAT signaling pathway in MF pathogenesis was elucidated through the identification of the JAK2-V617F mutation in 50%-60% of MF patients.55 This mutation disrupts the autoinhibitory SH2 pseudokinase domain of JAK2, leading to constitutive activation and subsequent STAT-mediated transcriptional upregulation.