Further research is needed to determine the dissociation constant (Kd) for the arginine‐RBM39 interaction, assess whether it aligns with arginine fluctuations during hepatocellular carcinoma (HCC) progression, and elucidate how arginine‐bound RBM39 influences the transcription of downstream metabolic genes. This evidence concerns the gene RBM39 and hepatocellular carcinoma.