Among these, polyethyleneimine (PEI) is one of the widely used gene carriers, condensing DNA into nanocomplexes to facilitate endocytosis.[48, 49] Based on this, we designed a PEI/DNA delivery system coated with RCC cell membranes for efficient delivery of piR‐RCC plasmids, aiming at targeted therapy for RCC (Figure 7A). This evidence concerns the gene PIR and renal cell adenocarcinoma.