YBX1 and renal cell carcinoma: YBX‐1 predominantly localizes in the cytoplasm, where it binds to mRNA, regulating stability, translation, and other processes.[7, 8, 9, 10, 11, 12, 13] Nuclear‐located YBX‐1 functions as a transcription factor or RNA splicing factor to participate in gene regulation.[14, 15, 16, 17] Many studies have confirmed that YBX‐1 is involved in various tumorigenic events, including tumorigenesis, proliferation, metastasis, and drug resistance.[18, 19, 20, 21, 22, 23, 24] However, the mechanism of YBX‐1 nuclear localization in RCC progression remains to be elucidated.