Among these, polyethyleneimine (PEI) is one of the widely used gene carriers, condensing DNA into nanocomplexes to facilitate endocytosis.[48, 49] Based on this, we designed a PEI/DNA delivery system coated with RCC cell membranes for efficient delivery of piR‐RCC plasmids, aiming at targeted therapy for RCC (Figure 7A). The gene discussed is PIR; the disease is renal cell carcinoma.