By activating WNT and SHH signaling pathways, the iPSCs were differentiated into hindbrain organoids containing 5‐HT neurons (5‐HT‐organoids), which were utilized to evaluate differences in therapeutic responses to escitalopram oxalate concerning neuropsychiatric symptoms in AD patients.[78] In 2024, Pang et al. The gene discussed is SHH; the disease is Alzheimer disease.