PARK7 and Parkinson disease: Loss of DJ1 diminishes the ability of astrocytes to provide metabolic support, triggering an inflammatory phenotype that results in neurodegeneration.[179] In another study, researchers identified a U1‐dependent splicing defect in an in vitro model of PD associated with Parkinson disease protein 7 (PARK7), leading to a sharp reduction in DJ1 protein levels and subsequent mitochondrial dysfunction.