For instance, by activating the WNT and SHH signaling pathways, iPSCs can be induced to differentiate into 5‐HT‐organoid, which hold great promise for investigating neuropsychiatric symptoms in AD patients.[78] These in vitro culture systems provide an efficient and highly relevant platform for investigating human neural development, tissue structural formation, and neurological disorders. This evidence concerns the gene SHH and Alzheimer disease.