COX8A and Sepsis: Specifically, we identified Cox4i1, Cox8a, and Ndufa4 as three hub genes in the common modules, suggesting an important role for these three genes and their protein products within the electron transport chain, the mitochondrial ATP synthesis, and thermogenesis.[42] Of note, all three genes have already been confirmed as drug targets according by the DrugBank database,[62] and appear to be relevant also to sepsis according to our data.