Actually, renal disease is highly prevalent in Cockayne syndrome patients’ clinical presentations.[60] Interestingly, recent work demonstrates that injured kidney cells can exert systemic effects beyond their local microenvironments, including on the central nervous system, highlighting the kidney's role in inter‐organ signaling.[61] In this study, we show that Zfas1 deficiency impedes DNA damage repair in mice, with marked physiological consequences in the kidney, suggesting that proximal tubule cells may be a key target of DNA damage‐induced transcriptional stress. This evidence concerns the gene ZFAS1 and kidney disorder.