Other UBE2 enzymes, such as UBE2I, UBE2Q1, UBE2E1, and UBE2Z, display varied regulatory patterns in neurodegenerative diseases like frontotemporal dementia, suggesting the Ube2 family's extensive influence on neurodegeneration, inflammation, and cellular stress responses.50, 51, 55. Here, UBE2I is linked to frontotemporal dementia.