Given the intricate association between NEU1 and cardiac pathogenesis remaining ambiguous, the expression of Neu1 and its tight co‐expression genes in non‐failing healthy donors (NCM) tissue, hypertrophic cardiomyopathy (HCM), and dilated cardiomyopathy (DCM) were evaluated by Pearson's correlation analysis. This evidence concerns the gene NEU1 and hypertrophic cardiomyopathy.