The primary findings of the present study are as follows: (1) healthy women with a hxPE have attenuated AT2R-mediated vasodilation compared with matched women who had a healthy pregnancy, (2) acute inhibition of AT1R with losartan augmented AT2R-mediated vasodilation in women with a hxPE, and (3) exaggerated ang II vasoconstrictor sensitivity present in women after preeclampsia is driven, in part, by a reduction in AT2R-mediated responses. This evidence concerns the gene AGT and preeclampsia.