Considering that women with preeclampsia have increased AT1R expression in placental vessels and vascular endothelial cells during pregnancy [23,24,47] and have increased AT1R expression in skin biopsy samples after preeclampsia [13], we hypothesized that exaggerated AT1R-mediated constriction attenuates AT2R-mediated dilation after preeclampsia. The gene discussed is AGTR1; the disease is preeclampsia.