DEFB1 and adenocarcinoma: To directly test if the expression of BD‐1 is regulated by AhR, we used murine adenocarcinoma cells, MC38, and human colon carcinoma, Caco2 cells which were treated with I3C at 0.1, 1 and 10 μm and then treated with DSS (0.03%) for additional at 8, 16, and 24 h, to assess their impact on AhR expression in MC38 and Caco‐2 cells (data not shown).