Studies have shown that activation of CD40 signaling using anti‐CD40 antibody can cause colitis in T cell‐ and B‐cell‐deficient mice by increasing myeloid cell‐mediated production of IL‐23, IL‐1β, and IL‐12.[23] Our analysis detected a significant reduction in body weight (Figure S5B, Supporting Information), colon length (Figure S5C, Supporting Information) and an increased macroscopic colitis score (Figure S5D, Supporting Information) in anti‐CD40‐induced colitis mice. Here, IL1B is linked to colitis.