It is interesting to note that patients with IBD showed decreased expression of AhR,[19] and hBD‐1.[20] Moreover, a genetic variation in the gene encoding hBD‐1 is associated with IBD.[21] However, whether AhR activation regulates secretion of antimicrobial peptides such as BD‐1 in CECs during colitis has not been previously investigated. This evidence concerns the gene AHR and colitis.