TP53 and B-cell chronic lymphocytic leukemia: A recent systematic review and meta-analysis confirmed that, in addition to clinical stage evaluation [60], the best practice to initial prognosis in CLL patients should include the chronic lymphocytic leukemia international prognostic index (CLL-IPI), which combines 5 parameters (age, clinical stage, TP53 status, IGHV mutational status, and serum B2-microglobuli) [61].