In the diagnosis of CLL, CD5, CD19, CD20, CD23, surface or cytoplasmic kappa, and lambda light chains are regarded as essential markers, and CD10, CD43, CD79b, CD81, CD200, and ROR1 as additional targets useful in the differential diagnosis from other small B-cell lymphomas/leukemias [3]. Here, CD5 is linked to B-cell chronic lymphocytic leukemia.