ITGB3 and osteosarcoma: Given that osteosarcoma has osteogenic differentiation potential, cells at different stages of differentiation exhibit variable sensitivity to IR, and ITGB3 has the potential to modulate osteogenic differentiation, we delved into the mechanism underlying the radiosensitizing effect of ITGB3-KD in osteosarcoma, particularly its influence on osteogenic differentiation.