Second, while this study provides initial evidence that ITGB3-KD promotes osteogenic differentiation and induces radiosensitization in osteosarcoma through activation of the JNK/c-JUN/RUNX2 pathway, the mechanistic crosstalk between osteogenic differentiation and other radiosensitization-related pathways (e.g., DNA damage repair pathways) remains uncharacterized. Here, ITGB3 is linked to osteosarcoma.