G6PC1 and Hyperglycemia: Researchers also found that FTO can facilitate mRNA expression of FOXO1, fatty acid synthase (FASN), G6Pase catalytic subunit (G6PC), and diacylglycerol acyltransferase 2 (DGAT2), whose increased expression is closely associated with hyperglycaemia and dyslipidaemia in T2DM patients [78].