For specific endometrial pathways, hyperandrogenism only plays a role in the presence of hyperinsulinemia, such as the impaired endometrial lipocalin signaling pathway [92], and DHT-enhanced up-regulation of prokineticin 1 (PROK1) in human embryonic stromal cells (hESC) only in combination with insulin [93]. This evidence concerns the gene PROK1 and hyperinsulinism.