By inhibiting METTL3 expression, butyric acid ameliorated LPS-induced apoptosis and oxidative stress and suppressed the expression of inflammatory cytokines, for example, PPAR-γ and GLUT4 levels were reduced in the PCOS model mice, but administration of butyric acid resulted in elevated levels of PPAR-γ and GLUT4 as well as reduced levels of IL-6, NLRP3 and TNF-α [30] (Fig. 3). This evidence concerns the gene TNF and polycystic ovary syndrome.