Another study of 237 MASLD patients revealed that LBP was associated with NASH severity and liver fibrosis, with higher LBP linked to inflammation, fibrosis, and the TM6SF2 rs58542926 T allele—a genetic variant associated with impaired lipid metabolism and increased MASLD/NASH risk [202]. Here, TM6SF2 is linked to metabolic dysfunction-associated steatohepatitis.