NF1 and optic pathway glioma: Individuals with missense variants that affect the NF1 codons 844–848 have a statistically higher risk of developing spinal neurofibromas, plexiform neurofibromas, and optic pathway gliomas, whereas the pathogenic recurrent missense variants of p.Met1149, p.Arg1276, and p.Lys1423 are correlated with the Noonan-like phenotype [12].