Conversely, nonallergic asthma, affecting 10–40% of asthma cases (Baos et al. 2018), is characterized by an acute inflammatory response involving cytokines such as IL-1, IL-6, IL-8, and TNF-α, leading to neutrophil infiltration and airway inflammation (Sze et al. 2020). The gene discussed is TNF; the disease is asthma.