For example, EVs from adipose mesenchymal stem cells (AdMSCs) that overexpress miR-15a reduce CRC immune evasion by affecting the KDM4B/HOXC4/PD-L1 pathway [89].Thus, reducing EV-miR-21-5p and EV-miR-200a or increasing EV-miR-15a could be a promising methods for immunotherapy in CRC patients. Here, HOXC4 is linked to colorectal carcinoma.