Furthermore, mechanistic experiments revealed that BC-derived EV-miR-106b-5p and EV-miR-18a-5p synergistically upregulated PD-L1 expression in M2 TAMs by modulating the PTEN/AKT and PIAS3/STAT3 pathways, leading to enhanced BC cell invasion and metastasis[120]. This evidence concerns the gene STAT3 and breast cancer.