Another key growth factor TGFβ that stimulate pulmonary fibrosis during COVID-19 acute lung injury are produced due to JAK1-STAT1 dysregulation led hyperactivation of STAT3 which is a key transcription factor for the overexpression of harmful IL-6 that stimulates transforming growth factor-1beta (Matsuyama et al. 2020) (Fig. 1). The gene discussed is JAK1; the disease is COVID-19.