LMNA and familial dilated cardiomyopathy: A familial cause is implicated in 25–35% of cases and many pathological and likely pathological variants are associated with worse cardiovascular outcomes [51–53]. A study in 487 patients with DCM showed that carriers of desmosomal and lamin A/C (LMNA) genetic variants experienced a significantly higher rate of ventricular arrhythmias and sudden cardiac death (SCD), independent of ejection fraction [54].