FDX1 and neoplasm: This study provides a thorough examination of the expression, genetic alterations, and prognostic inferences of cuproptosis-related genes in STAD, with a particular emphasis on FDX1. Our key findings include: (1) differential expression of multiple cuproptosis-related genes between tumor and normal tissues; (2) significant association of FDX1 expression with improved survival outcomes; (3) correlation between FDX1 expression and immune cell infiltration patterns; and (4) potential predictive value of FDX1 for chemotherapy response.