In our study, we found that macrophages expressing pathogenic variants associated with CAPS increase the expression of the Acod1 gene and upregulate genes related to the Nrf2 pathway, suggesting that itaconate could be regulating sterile inflammatory flares in the constitutive activation of p.D305N NLRP3 inflammasome. The gene discussed is ACOD1; the disease is cryopyrin-associated periodic syndrome.