DOT1L and neoplasm: As mentioned above, NK cell differentiation into an ILC1-like state in solid tumors occurs rapidly after NK cell infiltration, and while most control NK cells acquire an intILC1 or ILC1 phenotype in orthotopic MC38 tumors, the proportion of ILC1 cells is greater in tumors of mice lacking DOT1L in their NK cells, which is correlated with poorer tumor control.