TP53 and neoplasm: We observed no difference in p53 aggregate levels in plasma between those tumours that were mutant for TP53 (n = 32) or wild type (n = 55) (Mutant vs WT (Median (IQR)): 31.77 (17.670, 54.535) vs 27.528 (11.206, 53.666), Mann–Whitney U-test p value = 0.318) (Supplementary Fig. S5).