The DMR analysis in female offspring showed striking signals in obesity-related genes including RNASE1 (which regulates feeding habit83 and childhood obesity84), CPT1A (known to be involved in fatty acid oxidation)85, SSTR1 (growth hormone synthesis)86, DGKZ (lipid metabolism)87HIF3A (childhood obesity)88 and ADAMTS16 (related to anorexia nervosa)89. The gene discussed is ADAMTS16; the disease is obesity due to melanocortin 4 receptor deficiency.