INS and obesity due to melanocortin 4 receptor deficiency: In male offspring, associated dmCpGs were linked to known obesity-related genes including B4GALNT4 (cg25020933, cg15762098), ADCY9 (insulin secretion and thyroid hormone synthesis) (cg00610508), ADRB1 (cg13848598) and ATP10D (cg14009629).