In their meta-analysis Wang et al [13] evaluated 11 immunohistochemical markers in esophageal SCC with prognostic significance, including vascular endothelial growth factor, Cyclin D1, and p-mTOR, associated with poor outcomes, and P16 and E-cadherin, linked to favorable prognosis. This evidence concerns the gene MTOR and esophageal squamous cell carcinoma.