Furthermore, the beneficial effects of SBDS on the reduction of redness in rosacea patients may also stem from its impact on inflammatory molecules produced by other cell types present in the skin and/or lesions, such as neutrophils36 Previous studies have already demonstrated that SBDS inhibits VEGF, LL-37, ROS, and Ca2+ release in neutrophils19. The gene discussed is CAMP; the disease is rosacea.