The influence of GH-RH antagonists on animal models of BPH had not been investigated hence, we evaluated the effects of the GH-RH antagonist JMR-132 given at doses of 40 μg/day, MIA-313 at 20 μg/day, and MIA-459 at 20 μg/day in testosterone-induced BPH in Wistar rats46. The gene discussed is GHRH; the disease is benign prostatic hyperplasia.