USP8 and posterior cortical atrophy: It was found that the effect of PAAG stiffness on the CD8+ T cells cytotoxicity to USP8KO DU145/PC-3 cells and USP8C786A DU145/PC-3 cells was lost, indicating the vital role of USP8 and its deubiquitinating enzyme activity in the process of matrix stiffness promoting immune escape of PCa (Fig. 3K–N).