Take together, our study demonstrated that the degradation of MHC-1 and abundance of PD-L1 in PCa were responsible for the direct causes of PCa immune evasion, and high PAAG stiffness-induced USP8 high expression is the main molecular mechanism of the degradation of MHC-1 and abundance of PD-L1 in PCa. Here, CD274 is linked to posterior cortical atrophy.