We found that pretreatment with the proteasome inhibitor MG132 increased PD-L1 protein level in PCa cells, whereas the lysosome inhibitor 3-MA failed to affect PD-L1 protein expression (Fig. 7D), suggesting that PD-L1 was degraded through ubiquitin-proteasome pathway in PCa. This evidence concerns the gene CD274 and posterior cortical atrophy.