PLWHA under age 18 years.Diagnosed with HIV and in care for less than 6 months.PLWHA not having cognitive ability to consent.Having<200 cells/mm3 CD4 count or viral load>200, severe complications/ co-morbidities including cardiovascular diseases, malignancies, pneumonia and requiring specialised treatment at secondary/tertiary health facility).Persons attending clinic for pre-counselling & testing services including prevention of mother-to-child transmission. The gene discussed is CD4; the disease is susceptibility to pneumonia measurement.