In this study, we categorized the phenotypes of FSGS-associated TRPC6 variants as follows: (1) delayed inactivation with no alteration in the peak current density (53%); (2) delayed inactivation with increased peak current density (33%); (3) increased peak current density with no delayed inactivation (7%); and (4) inactivation and peak current density did not differ from WT (7%). This evidence concerns the gene TRPC6 and focal segmental glomerulosclerosis.