Of note, a homozygous variant (c.787G>A [p.Arg261Gln]) in POPDC3, which affects the paralogous residue of p.Arg263 in POPDC2 (families B and C), has been associated with muscular dystrophy without cardiac arrhythmia (MIM: 604577).28 Here, POPDC3 is linked to cardiac rhythm disease.