Other intriguing associations are found with the FHR family (Poppelaars et al., 2021a), where as opposed to the deletion of FHR3/FHR1 being associated with a higher risk of SLE, there is a lower risk of developing IgA nephropathy (IgAN) (Gharavi et al., 2011). Here, CFHR1 is linked to systemic lupus erythematosus.