Calu-3 cellswere silenced for the expression of PAR2 (Figure S3) and were infected with both the Wuhan variant and the Omicronvariant, i.e., the latest viral variant of concern, of SARS-CoV-2;in both cases, we observed significant reductions in viral infection(approximately 50% and 35%, respectively) (Figure C). The gene discussed is F2RL1; the disease is viral infectious disease.