Among the ten candidate hub genes, we found that 8 hub genes were differentially upregulated in HBV and COVID-19, so we further narrowed the scope of the study to 8 hub genes, including CDK1, E2F7, E2F8, TYMS, KIF20A, CENPE, TPX2, HMMR. The gene discussed is E2F8; the disease is COVID-19.