While previous studies and reviews have highlighted several mechanisms that mediate the involvement of the AhR/CYP1 pathway in the pathogenesis of DM [13], to our knowledge, there is a scarcity of research and a lack of clear understanding regarding the crosstalk between the AhR/CYP1 pathway and epigenetic modifications in the context of insulin resistance and diabetes. This evidence concerns the gene CYP1A1 and Insulin resistance.