EPHA2 and glioblastoma: Importantly, EphA2 is overexpressed not only in various humanmalignanciesincluding melanoma, lung cancer, breast cancer, ovarian cancer, andGBM,,−,  but also in GSCs, allowingthese cells to invade the brain more effectively and maintain theirstem cell-like properties.,, The overexpression in GSCs contributes to the aggressive behaviorof GBM and promotes resistance to conventional therapies.