Wheeze phenotype is characterized by basal cell activation and up-regulation of immune signaling pathways [interleukin-17 (IL-17), tumor necrosis factor (TNF), and chemokines], RAS advanced glycation end products (AGE) and their receptor, RAGE, thyroid signaling, and growth factor/remodeling pathways [vascular endothelial growth factor (VEGF), EGF, and pathways in cancer (WNT and Notch/Jagged)], among others in our dataset. The gene discussed is TNF; the disease is cancer.