Once HIV-1 has breached the mucosal epithelium, possibly aided by microabrasions, Langerhans cells (LCs), tissue-resident macrophages, and DCs, such as cDC2 whose findings were largely in line with, can capture HIV-1 mainly via Langerin, Siglec-1, and C-type lectin receptors (such as DC-SIGN on macrophages [39–41]), facilitating trans-infection of tissue resident CD4 + T cells [39,42–52]. The gene discussed is CD4; the disease is infection.