Adiponectin, released by either adipocyte or ASCs [19], normally is decreased in obesity [43] In contrast, in our study the proinflammatory cytokines such as TNF-alpha or IL-6 were strongly reduced in the presence of LIPUS, reducing their secretion by ASCs as they maintained a stemness phenotype, with a non-inflammatory profile [19, 86, 87]. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.