In addition, autocrine and paracrine regulatory loops involving angiotensin as proinflammatory and adiponectin as an anti-inflammatory signal can further modulate the cross talk between adipocytes and adipose tissue macrophages [29, 42] that decreased under conditions of obesity, insulin resistance, and type II diabetes [42, 43]. This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.