Several nickel-based compounds such as Nickel(II) N-(2-hydroxyacetophenone) glycinate (NiNG) and nickel(II)-bis (thiosemicarbazone) showed considerable efficacy in multidrug resistance that involves reactive oxygen species (ROS)-mediated redox imbalance for regulation of caspase-3-dependent apoptosis against human breast (MCF7) and lung (A549) cancer cells [14, 15]. This evidence concerns the gene CASP3 and cancer.