In contrast, PTTG1 acts as a regulator of sister chromatid separation during cell division under physiological conditions (Zou et al., 1999), which is closely linked to genetic instability, aneuploidy, tumor progression, invasion, and metastasis (Heaney et al., 2000; Ramaswamy et al., 2003; Kim et al., 2005; Yu et al., 2003; Teveroni et al., 2021; Romero et al., 2001). Here, PTTG1 is linked to neoplasm.