IL6 and inflammatory bowel disease: Notably, the JAK/STAT signaling pathway is highly involved in the pathogenesis of IBD [80], mediating the function of several inflammatory cytokines involved in intestinal inflammation, such as IL-2, IL-4, IL-6, IL-7, IL-9, IL-12, IL-15, IL-21, IL-23, and IFN-γ [81].