However, the absence or low expression of CD38 was significantly correlated with splenomegaly (p = 0.0444), high level of lactate dehydrogenase (p = 0.01), initiation of a treatment (p = 0.0325), a decreased platelet count (p = 0.0063), an increased BM (p < 0.0001) (Figure 4) and blood tumoral infiltration (p = 0.0019) and the presence of a CXCR4 mutation (S338 and others) (p < 0.0001) (Figure 4). The gene discussed is CXCR4; the disease is Splenomegaly.