CDH1 and posterior cortical atrophy: As shown in Figure 7C, a recruitment profile of BRD4 and H3K27ac comparable with that in PC3 and 22Rv1 cells (Figure 4) was observed in PCa-derived OSC#120 [GS 7 (4 + 3), pT3b] as well as in OSC#97 [GS 6 (3 + 3), pT2c] and OSC#99 [GS 7 (3 + 4), pT2c] (Figure S5), with higher recruitment of BRD4 and H3K27ac in first intron for CDH1 (site II) and proximal promoter for ITGB4 (site III) regulatory regions.