H19 and Familial prostate cancer: To assess whether the BET family proteins BRD2, BRD3, and BRD4 are involved in the regulation of the above H19/cell adhesion molecules’ circuitry, the PC-3 and 22Rv1 prostate cancer cell lines were treated with JQ1, a potent inhibitor of the BET family of acetyl-lysine recognition motifs, including the BRD2, BRD3, BRD4, and BRDT bromodomains.