As shown in Figure 7C, a recruitment profile of BRD4 and H3K27ac comparable with that in PC3 and 22Rv1 cells (Figure 4) was observed in PCa-derived OSC#120 [GS 7 (4 + 3), pT3b] as well as in OSC#97 [GS 6 (3 + 3), pT2c] and OSC#99 [GS 7 (3 + 4), pT2c] (Figure S5), with higher recruitment of BRD4 and H3K27ac in first intron for CDH1 (site II) and proximal promoter for ITGB4 (site III) regulatory regions. This evidence concerns the gene BRD4 and posterior cortical atrophy.