High levels of PDK are a poor prognostic marker for AML [77] and the expression of miR-15b-5p is inversely associated with PDK4 in osteosarcoma [78], HepG2 cells [79], and recurrence of hepatocellular carcinoma [80]; therefore, this study highlights an important role for the miR-15b-5p/PDK4 axis in BzBP-induced AML malignancy. Here, PDK4 is linked to osteosarcoma.