Aberrant LLPS has been implicated in the formation of amyloid-like aggregates in diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), where phase-separated intermediates composed of IDPs, such as FUS and TDP-43, transition to pathological solid states [123]. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.