These proteins with high intrinsic disorder and LLPS propensity, such as myristoylated alanine rich C-kinase substrate (MARCKS; UniProt ID: P29966) and nuclear transition protein 2 (TNP2; UniProt ID: Q05952) could serve as potential targets for understanding acrosome deformities and infertility. The gene discussed is TNP2; the disease is Infertility.