Recent studies identify an imbalance in cytokine levels in fibromyalgia patients, characterized by elevated tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and interleukin-8 (IL-8) [30], with serum concentrations of IL-6 and IL-8 significantly correlating with disease severity [31,32]. This evidence concerns the gene TNF and fibromyalgia.