IRF7 and viral infectious disease: However, as in the case of Huh7.5, the presence of IRF7 had no impact on SeV replication (Fig. 6F) and only slightly but significantly increased IFIT1 induction, but dramatically increased IFNB mRNA levels by ca. 100-fold, suggesting that Huh7.5 reconstituted with relevant PRRs can serve as a valid model for ISG induction upon virus infection.